Within a world-system characterized by processes and dynamics whose interconnections and interdependencies increase exponentially each day, we are passing through an extremely delicate and complex phase of global mutation. What we are witnessing is a radical overturn of the complex interaction between natural (biological) and cultural evolution. The ongoing paradigm shift and profound anthropological transformation create new dimensions, openings, epistemological implications that require new thinking and new thought, as well as differentapproaches and methods.